Aging-associated gene 4 protein, aging-associated protein 4, Apo-J, ApoJalpha, ApoJbeta, Apolipoprotein J, CLI, Clusterin, Clusterin alpha chain, Clusterin beta chain, Complement cytolysis inhibitor, Complement cytolysis inhibitor a chain, Complement cytolysis inhibitor b chain, complement lysis inhibitor, Complement-associated protein SP-40, 40, Ku70-binding protein 1, NA1/NA2, SGP-2
Clusterin in brain and cerebrospinal fluid in Alzheimer's disease. K. Engelska. 602 Synaptic elimination and the complement system in Alzheimer´s disease. M.
engelska. ApoJ Protein. Apolipoprotein J. Complement Associated Protein SP 40,40. Complement Lysis Inhibitor. Complement-Associated Protein apolipoprotein A1 but also specific proteins involved in immune response, such as complement factors.
2007-03-30 · It consists of two 40-kD chains, alpha and beta, covalently joined by disulfide bonds. They established that SP-40,40 is a member of the human complement system by directly demonstrating its presence within the S-protein-containing soluble variant of the C5b-9 complex, SC5b-9. SP-40,40 is also called complement lysis inhibitor or clusterin. Clusterin, another soluble complement-regulatory cultured rat glomerular mesangial cells stimulated by sublytic protein, may also play an important role in immune-complement attack. We also demonstrated that in comparison mediated glomerular injury, as perfusion of isolated kid-with control rats, both a marked increase in clusterin mRNA Clusterin has been implicated in a variety of activities including programmed cell death, regulation of complement mediated cell lysis, membrane recycling, cell-cell adhesion, and src induced transformation. As part of the attack complex of complement, it acts as a complement inhibitor.
CLUS_H Clusterin CLU EM,ENDO LungCancers, Secreted. UniProt, UMAN BenignNodul Literature, es, Symptoms Detection, Prediction CMGA_ Chromogra
PDF) Complement as a diagnostic tool in immunopathology in immunopathology. Complement involvement in kidney diseases: From .
Glial Cell Responses, Complement and Clusterin in the Central Nervous System Following Dorsal Root Transection1998Ingår i: Glia, ISSN 0894-1491, E-ISSN
ment lysis inhibitor, or CLI; SGP-2; TRPM-2; apolipoprotein. J)’ is a 70-kDa glycoprotein found at concentrations of 50-. 100 pg/ml in normal human plasma and at about 10-fold. higher concentrations in human seminal plasma (1-4). Ini-. 2014-04-17 · Clusterin, vitronectin, the complement derived anaphylotoxin C3a, as well as the terminal C5b-9 soluble complex were quantitated in AH specimens, thawed immediately before the assays, using capture ELISA in accordance with the respective manufacturers' protocols, as described previously. 27 In all cases, assessment of the respective protein concentrations in the XFG and non-XFG specimens was determined by interpolation using standard curves.
RESULTS. Atomic-force microscopy examination of lenses with exfoliation syndrome (XFS) revealed a dense fibrillar network on the anterior, aqueous-bathed surface of the lens, while the epithelial side displayed no discernible structural features at the same
The same phenomenon was found in serum taken from the siblings and the mother but not in the sample from the father and controls. Addition of clusterin to patient serum did not inhibit complement activation on platelets. The Q433P mutant, in isolated form, was further studied by binding to the components of the terminal complement complex. Background —The complement system is implicated in the pathogenesis of atherosclerosis.
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S R Partridge , M S Baker , M J Walker , and M R Wilson Institute for Molecular Recognition, University of Wollongong, New South Wales, Australia. s.partridge@uow.edu.au Clusterin/human complement lysis inhibitor (CLI) is incorporated stoichiometrically into the soluble terminal complement complex and inhibits the cytolytic reaction of purified complement components C5b-9 in vitro. Using an anti-clusterin affinity column, we found that an additional protein componen … Clusterin is a 75 - 80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis.
Clusterin protects cells by inhibiting complement and colocalizes with complement on jeopardized human cardiomyocytes after infarction.
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1 Jun 2015 a major amplification step in the early complement activation cascade, whereas clusterin (179), S-protein (180), and CD59 inhibit formation of
It has a tendency to aggregate cells, including Sertoli cells and erythrocytes. It binds to the terminal complement Clusterin is a plasma protein that may play an important role in regulating C5b7-8 Complement activation is known to occur and induce unspecific inflammation around the biomaterials. Human vitronectin (Vn) and clusterin (Clu), two potent Complement function or activity test allows for the determination of whether the protein is present and whether it has normal functional activity. A wide range of Consistently, complement regulators, such as Vitronectin, Clusterin, and MCP, are highly expressed in drusen and RPE cells adjacent to drusen [30, 81, 82].
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Aging-associated gene 4 protein, aging-associated protein 4, Apo-J, ApoJalpha, ApoJbeta, Apolipoprotein J, CLI, Clusterin, Clusterin alpha chain, Clusterin beta chain, Complement cytolysis inhibitor, Complement cytolysis inhibitor a chain, Complement cytolysis inhibitor b chain, complement lysis inhibitor, Complement-associated protein SP-40, 40, Ku70-binding protein 1, NA1/NA2, SGP-2
With high purity, high biological activity, high stability, and other superior features, you can use this Human Clusterin protein for relevant bioassay and related research. Details for CPTC-CLU-1. CLI; APOJ1; KUB1; TRPM-2; CLU1; CLU2; SGP-2; SP-40; Apolipoprotein J; Complement Cytolysis Inhibitor; Complement-Associated Protein SP-40,40; Ku70-Binding Protein 1; Testosterone-Repressed Prostate Message 2; NA1/NA2; SGP2; TRPM2; Clusterin (Complement Lysis Inhibitor, SP-40,40; Clusterin (Complement Lysis Inhibitor, SP-40,40, Sulfated Glycoprotein 2,Testosterone Clusterin is considered to be involved in protecting homologous cells from complement attack by inhibiting the lytic action of the membrane attack complex. We 5 May 2016 Clu also interacts with a broad spectrum of molecules (such as lipids, components of the complement system, amyloid-forming proteins, (SGP-2), secreted glycoprotein gp80, complement-associated protein SP-40, Clusterin is a highly conserved glycoprotein that functions primarily as an HGNC Previous name, "clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)". in the expression of complement receptor 2 on B cells upon. HIV infection. Clusterin. Human clusterin (synonyms: complement lysis irJiibitor, CLI; sulfated 5 Mar 2021 Clusterin · Testosterone-Repressed Prostate Message 2 · Sulfated Glycoprotein 2 · Apolipoprotein J · TRPM-2 · SGP-2 · KUB1 · Complement- 5 Mar 2021 Aim: Obstructive sleep apnea (OSA) activates the complement system; however, the levels of membrane attack complex (MAC) are unaltered Clusterin binding to C5b-8-(FITC-C9)1 caused fluorescence quenching similar to that of unlabeled C9 of clusterin in complement inhibition is supported by its.